Open AccessClinical and neurophysiological findings in oligoclonal band negative multiple sclerosis patients
Author(s) -
Šarlota Mesaroš,
Jelena Drulović,
Z Lević
Publication year - 2003
Publication title -
srpski arhiv za celokupno lekarstvo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 17
eISSN - 2406-0895
pISSN - 0370-8179
DOI - 10.2298/sarh0304122m
Subject(s) - multiple sclerosis , medicine , abnormality , expanded disability status scale , cerebrospinal fluid , magnetic resonance imaging , somatosensory evoked potential , brainstem , audiology , anesthesia , radiology , psychiatry
Besides magnetic resonance imaging, the presence of locally produced oligoclonal IgG bands (OCB) in the cerebrospinal fluid (CSF) is the most consistent laboratory abnormality in patients with multiple sclerosis (MS). The most sensitive method for the detection of CSF OCB is isoelectric focusing (IEF) [6]. Occasional patients with clinically definite MS lack evidence for intrathecal IgG synthesis [7, 8]. This study was designed to compare clinical data and evoked potential (EP) findings between CSF OCB positive and OCB negative MS patients.