Open AccessSlowing down of chronic renal failure progression with captopril in spontaneously hypertensive rats with adriamycin nephropathy
Author(s) -
Jovanović Db,
Jovović Dj,
Jasmina Varagić,
J Dimitrijević,
Z Dragojlović,
Ljubica Djukanović
Publication year - 2002
Publication title -
srpski arhiv za celokupno lekarstvo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 17
eISSN - 2406-0895
pISSN - 0370-8179
DOI - 10.2298/sarh0204073j
Subject(s) - captopril , medicine , blood pressure , hypertensive nephropathy , nephropathy , endocrinology , angiotensin converting enzyme , spontaneously hypertensive rat , kidney , urology , diabetic nephropathy , diabetes mellitus
The role of hypertension in chronic renal failure (CRF) progression was described in 1914 by Volhard and Fahr [1], in 1940 by Rite and colleagues [2] and subsequently many studies described the effects of various antihypertensive drugs on regulation of blood pressure and CRF progression. The recent experimental and clinical studies especially emphasized the role of angiotensin converting enzyme (ACE) inhibitors in the regulation of hypertension and slowing down of CRF progression, but there are still issues for discussion and disagreement [2-14]. The aim of this study was to analyse the effects of captopril on clinical, biochemical and morphological changes in spontaneously hypertensive rats (SHR) with adriamycin (ADR) nephropathy.