Slowing down of chronic renal failure progression with captopril in spontaneously hypertensive rats with adriamycin nephropathy | Zendy

Dijana Jovanović | Zendy; Djurdjica Jovovic | Zendy; Jasmina Varagić | Zendy; J Dimitrijević | Zendy; Z Dragojlović | Zendy; Ljubica Djukanović | Zendy

Open Access

Slowing down of chronic renal failure progression with captopril in spontaneously hypertensive rats with adriamycin nephropathy

Author(s) -

Dijana Jovanović,

Djurdjica Jovovic,

Jasmina Varagić,

J Dimitrijević,

Z Dragojlović,

Ljubica Djukanović

Publication year - 2002

Publication title -

srpski arhiv za celokupno lekarstvo

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.135

H-Index - 17

eISSN - 2406-0895

pISSN - 0370-8179

DOI - 10.2298/sarh0204073j

Subject(s) - captopril , medicine , blood pressure , hypertensive nephropathy , nephropathy , endocrinology , angiotensin converting enzyme , spontaneously hypertensive rat , kidney , urology , diabetic nephropathy , diabetes mellitus

The role of hypertension in chronic renal failure (CRF) progression was described in 1914 by Volhard and Fahr [1], in 1940 by Rite and colleagues [2] and subsequently many studies described the effects of various antihypertensive drugs on regulation of blood pressure and CRF progression. The recent experimental and clinical studies especially emphasized the role of angiotensin converting enzyme (ACE) inhibitors in the regulation of hypertension and slowing down of CRF progression, but there are still issues for discussion and disagreement [2-14]. The aim of this study was to analyse the effects of captopril on clinical, biochemical and morphological changes in spontaneously hypertensive rats (SHR) with adriamycin (ADR) nephropathy.

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