Open AccessInfluence of radiation dose in computed tomography on antioxidant enzyme activity in rabbit erythrocytes
Author(s) -
Branislava Mitrovic,
F Olivera Ciraj-Bjelac,
Zorana Oreščanin-Dušić,
P Dusko Blagojevic,
Aleksandra NikolićKokić,
R Nikola Tatalovic,
E Nikola Krstic,
V Mirjana Lazarevic-Macanovic
Publication year - 2017
Publication title -
nuclear technology and radiation protection
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 16
eISSN - 1452-8185
pISSN - 1451-3994
DOI - 10.2298/ntrp1704342m
Subject(s) - antioxidant , enzyme , computed tomography , enzyme assay , antioxidant capacity , tomography , nuclear medicine , medicine , chemistry , biochemistry , radiology
The objective of this study was to assess the radiation dose in computed tomography examinations of rabbits using different examination protocols and to correlate these values with the activity of antioxidant enzymes in their red blood cells following irradiation. The presented results revealed that a single, routine computed tomography scan exposure led to a different response of the activity of antioxidant enzymes in red blood cells regarding both dose and time. The results indicate that there is a dose threshold that is about 25 mGy. Doses below that level do not produce any significant changes in the level of antioxidant enzymes activity. On the other hand, the level just above that threshold had a significant impact on the antioxidant defence, but in a relatively short time period (2 hours after exposure), compared to the higher dose that requires a longer adaptive period.