Influence of radiation dose in computed tomography on antioxidant enzyme activity in rabbit erythrocytes | Zendy

Marko Mitrović | Zendy; Olivera CirajBjelac | Zendy; Zorana Oreščanin-Dušić | Zendy; Duško Blagojević | Zendy; Aleksandra NikolićKokić | Zendy; Nikola Tatalović | Zendy; Nikola Krstić | Zendy; Mirjana Lazarević Macanović | Zendy

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Influence of radiation dose in computed tomography on antioxidant enzyme activity in rabbit erythrocytes

Author(s) -

Marko Mitrović,

Olivera CirajBjelac,

Zorana Oreščanin-Dušić,

Duško Blagojević,

Aleksandra NikolićKokić,

Nikola Tatalović,

Nikola Krstić,

Mirjana Lazarević Macanović

Publication year - 2017

Publication title -

nuclear technology and radiation protection

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.31

H-Index - 16

eISSN - 1452-8185

pISSN - 1451-3994

DOI - 10.2298/ntrp1704342m

Subject(s) - antioxidant , computed tomography , enzyme , enzyme assay , antioxidant capacity , radiation dose , nuclear medicine , medicine , chemistry , biochemistry , radiology

The objective of this study was to assess the radiation dose in computed tomography examinations of rabbits using different examination protocols and to correlate these values with the activity of antioxidant enzymes in their red blood cells following irradiation. The presented results revealed that a single, routine computed tomography scan exposure led to a different response of the activity of antioxidant enzymes in red blood cells regarding both dose and time. The results indicate that there is a dose threshold that is about 25 mGy. Doses below that level do not produce any significant changes in the level of antioxidant enzymes activity. On the other hand, the level just above that threshold had a significant impact on the antioxidant defence, but in a relatively short time period (2 hours after exposure), compared to the higher dose that requires a longer adaptive period.

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