Open AccessC-fos protein expression in the anterior amygdaloid area and nc. accumbens in the hypoxic rat brain
Author(s) -
Siniša Babović,
Sonja Žigić,
Branislav Šakić
Publication year - 2014
Publication title -
medicinski pregled
Language(s) - English
Resource type - Journals
eISSN - 1820-7383
pISSN - 0025-8105
DOI - 10.2298/mpns1412379b
Subject(s) - ligation , medicine , ischemia , external carotid artery , carotid arteries , occlusion , common carotid artery , ligature , limbic system , cardiology , central nervous system
. By examining the production of c-Fos protein, we analyzed the response to the ischemic attack in different brain tissue, two of which are regions of the limbic system: the anterior amygdaloid area and nc. accumbens. Material and Methods. We used the model of rat brain ischemia - four-vessel occlusion, and Pulsinelli?s method. The rats were treated in two ways, according to which they were divided into two groups: a total ischemia (ligation of four blood vessels, i.e. electrocauterization of the vertebral artery with bilateral ligation of the carotid artery - the so-called R-group rats), and transient ischemic attack (ligation of four blood vessels, i.e. electrocauterization of the vertebral artery, with mutual re-ligation of the carotid arteries in the form of transient ischemia - the so-called T-group rats, which can also be called ?pre-conditioned group?). Both groups had their own control group. Conclusion. We have concluded that parts of the brain with an important role for the survival have a strong expression of c-fos gene.