Age-related skin changes | Zendy

Aleksandra Levakov | Zendy; Nada Vučković | Zendy; Matilda Djolai | Zendy; Mihaela Mocko-Kacanski | Zendy; Snežana Božanić | Zendy

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Age-related skin changes

Author(s) -

Aleksandra Levakov,

Nada Vučković,

Matilda Djolai,

Mihaela Mocko-Kacanski,

Snežana Božanić

Publication year - 2012

Publication title -

medicinski pregled

Language(s) - English

Resource type - Journals

eISSN - 1820-7383

pISSN - 0025-8105

DOI - 10.2298/mpns1206191l

Subject(s) - dermis , ageing , medicine , dermoepidermal junction , skin aging , atrophy , skin biopsy , collagen fibres , papillary dermis , pathology , dermatology , biopsy , anatomy

Age-related skin changes can be induced by chronological ageing, manifested in subcutaneous fat reduction, and photo-ageing eliciting increased elastotic substance in the upper dermis, destruction of its fibrilar structure, augmented intercellular substance and moderate inflammatory infiltrate. Forty-five biopsy skin samples of the sun-exposed and sun-protected skin were analyzed. The patients were both males and females, aged from 17 to 81 years. The thickness of the epidermal layers and the number of cellular living layers is greater in younger skin. The amount of keratohyaline granules is enlarged in older skin. Dermoepidermal junction is flattened and the presence of elastotic material in the dermis is pronounced with age. The amount of inflammatory infiltrate is increased, the fibrous trabeculae are thickened in older skin and the atrophy of the hypodermis is observed. Chronological ageing alters the fibroblasts metabolism by reducing their life span, capacity to divide and produce collagen. During ageing, the enlargement of collagen fibrils diminishes the skin elasticity

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