Diagnostic significance of immunofluorescent tests in dermatology | Zendy

Ljiljana Medenica | Zendy; Dušan Škiljević | Zendy

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Diagnostic significance of immunofluorescent tests in dermatology

Author(s) -

Ljiljana Medenica,

Dušan Škiljević

Publication year - 2009

Publication title -

medicinski pregled

Language(s) - English

Resource type - Journals

eISSN - 1820-7383

pISSN - 0025-8105

DOI - 10.2298/mpns0912539m

Subject(s) - iif , medicine , bullous pemphigoid , pathology , pemphigus , dermatitis herpetiformis , antibody , pemphigoid , autoantibody , lupus erythematosus , anti nuclear antibody , vasculitis , dermatology , immunology , disease

Immunofluorescence (IF) is a laboratory technique introduced to dermatology in 1960s for the purposes of investigating the patophysiology and establishing the diagnosis of skin diseases, particularly autoimmune bullous diseases and connective tissues diseases. There are three basic types of IF techniques: the direct IF (DIF), which is used for the detection of antibodies and complement components fixed in the tissue, the indirect IF (IIF), which is used for the detection of circulating antibodies in patients' serum, and complement-fixed IIF (K-IIF), which is more sensitive in the detection of complement-binding circulating antibodies.

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