Open AccessKell immunization: A case report
Author(s) -
Marija Tasić,
Jelena Milošević,
Milan Stefanović,
Dragana Radović-Janošević,
Miljan Krstić,
Vladimir Antić
Publication year - 2009
Publication title -
medicinski pregled
Language(s) - English
Resource type - Journals
eISSN - 1820-7383
pISSN - 0025-8105
DOI - 10.2298/mpns0908369t
Subject(s) - medicine , fetus , pregnancy , antibody , disease , hemolysis , immunization , immunology , hemolytic disease of the newborn (abo) , antigen , obstetrics , immune system , genetics , biology
The frequency of occurrence of RhD alloimmunization, due to preventive protocols, is decreased in our country, but more often there are other antigens that emerge as a cause of hemolytic disease of fetus. The most prominent is Kell antigen, which promotes specific course of disease based on an innate pathogenetic mechanism. Anti-Kell antibody production is, just as in other atypical antibodies, provoked with transfusion of incompatible blood. Except for the immune-mediated hemolysis, anti-Kell antibodies can also inhibit the function of progenitor (erytroid and megakariocyte) cell lines.