Open AccessLynch syndrome I: A case report
Author(s) -
Živković,
Katić,
Jasmina Gligorijević,
Z Andelković,
Aleksandar Petrović,
Miljan Krstić
Publication year - 2008
Publication title -
medicinski pregled
Language(s) - English
Resource type - Journals
eISSN - 1820-7383
pISSN - 0025-8105
DOI - 10.2298/mpns0802079z
Subject(s) - medicine , microsatellite instability , lynch syndrome , proband , msh2 , colorectal cancer , mlh1 , malignancy , cancer , pms2 , asymptomatic , family history , dna mismatch repair , first degree relatives , genetic testing , oncology , mutation , genetics , gene , microsatellite , allele , biology
Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndromes I and II, accounts for about 5-8% of colorectal cancers. Lynch syndrome I is an autosomal dominant inherited disorder characterized by early onset of colorectal cancer, predominance of proximal and multiple tumors, and microsatellite instability. In order to identify HNPCC, the international "Amsterdam criteria" have been used.