Lynch syndrome I: A case report | Zendy

Vesna Živković | Zendy; Vuka Katić | Zendy; Jasmina Gligorijević | Zendy; Zlatibor Andjelkovic | Zendy; Aleksandar Petrović | Zendy; Miljan Krstić | Zendy

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Lynch syndrome I: A case report

Author(s) -

Vesna Živković,

Vuka Katić,

Jasmina Gligorijević,

Zlatibor Andjelkovic,

Aleksandar Petrović,

Miljan Krstić

Publication year - 2008

Publication title -

medicinski pregled

Language(s) - English

Resource type - Journals

eISSN - 1820-7383

pISSN - 0025-8105

DOI - 10.2298/mpns0802079z

Subject(s) - medicine , microsatellite instability , lynch syndrome , proband , msh2 , colorectal cancer , mlh1 , malignancy , cancer , pms2 , asymptomatic , family history , dna mismatch repair , first degree relatives , genetic testing , oncology , mutation , genetics , gene , microsatellite , allele , biology

Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndromes I and II, accounts for about 5-8% of colorectal cancers. Lynch syndrome I is an autosomal dominant inherited disorder characterized by early onset of colorectal cancer, predominance of proximal and multiple tumors, and microsatellite instability. In order to identify HNPCC, the international "Amsterdam criteria" have been used.

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