Open AccessDistribution of HLA antigens in families of patients with leukaemias
Author(s) -
Svetlana Vojvodić
Publication year - 2008
Publication title -
medicinski pregled
Language(s) - English
Resource type - Journals
eISSN - 1820-7383
pISSN - 0025-8105
DOI - 10.2298/mpns0802022v
Subject(s) - human leukocyte antigen , medicine , sibling , antigen , immunology , developmental psychology , psychology
Since the discovery of major histocompatibility complex influence on cause leukaemia in 1964, an HIA association with leukaemia in humans has been considered as a possible genetic risk factor that contributes to development of leukaemia. In addition to associations of several HLA antigens with leukaemias, it has been observed that patients with leukaemia have an increase in the frequency of HLA identical siblings, higher degree of HLA compatibility with their parents as well as higher parental HLA sharing rate in comparison to the families without patients suffering from leukaemia.