Development and role of comparative sequence analysis in medical virology | Zendy

Srdjan Stankov | Zendy

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Development and role of comparative sequence analysis in medical virology

Author(s) -

Srdjan Stankov

Publication year - 2006

Publication title -

medicinski pregled

Language(s) - English

Resource type - Journals

eISSN - 1820-7383

pISSN - 0025-8105

DOI - 10.2298/mpns0604138s

Subject(s) - genotyping , virology , computational biology , polymerase chain reaction , dna sequencing , virus classification , sequence analysis , medicine , sequence (biology) , reverse transcriptase , consensus sequence , biology , genetics , dna , genotype , gene , genome , base sequence

Development of the polymerase chain reaction and deoxyribonucleic acid sequencing techniques has enabled precise identification, classification and taxonomy of viruses. COMPARATIVE SEQUEENCE ANALYSIS: (Comparative sequence analysis methods can be used in medical virology for many practical purposes. They may be classified into three broad categories: I - reconstruction of genealogical relationships between individual viral isolatesfor detection and monitoring of sources, reservoirs and modes of viral transmission; II - virus genotyping, that is determination of relationships between genetic types of viruses and their phenotypic properties, which has important implications for immunoprophylaxis, therapy and prognosis of viral diseases, and III investigation of functional properties of defined viral sequences, of special importance for explanation of viral pathogenesis and design of antiviral drugs.

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