Open AccessMorphometric and immunohistochemical patterns of duodenal CCK-cells in rats with portacaval shunts
Author(s) -
Tatjana Radosavljević,
Nikola Todorović,
Danijela Vučević,
Branka Šikić
Publication year - 2006
Publication title -
medicinski pregled
Language(s) - English
Resource type - Journals
eISSN - 1820-7383
pISSN - 0025-8105
DOI - 10.2298/mpns0604124r
Subject(s) - portacaval shunt , medicine , immunohistochemistry , small intestine , endocrinology , pancreas , portacaval anastomosis , pathology , cirrhosis , portal hypertension
End-to-side portacaval shunt (PCS) performed in rats is an appropriate experimental model of chronic liver insufficiency. Functional hepatic injury followed by numerous metabolic and endocrine disorders develops, as well. Due to impaired functional hepatic activity in PCS and to the well known role of the liver in CCK metabolism and elimination, delayed CCK bloodstream elimination may be responsible for increased CCK-A receptor activity. Therefore, we investigated immunohistochemical and morphometric features of duodenal CCK-cells in rats with PCS.