Open AccessLambert-Eaton myasthenic syndrome: A rare manifestation of paraneoplastic syndrome in ovarian cancer: Case report
Author(s) -
Milica Zivaljevic,
Svetlana Popović,
Tamara Vujkov
Publication year - 2005
Publication title -
medicinski pregled
Language(s) - English
Resource type - Journals
eISSN - 1820-7383
pISSN - 0025-8105
DOI - 10.2298/mpns0510495z
Subject(s) - medicine , lambert eaton myasthenic syndrome , paraneoplastic cerebellar degeneration , pyridostigmine , ovarian cancer , weakness , cancer , muscle weakness , myasthenia gravis , surgery , immunology , autoantibody , antibody
Paraneoplastic neurological syndromes are rare non-metastatic complications of cancer that have an immune-mediated etiology. The Lambert-Eaton myasthenic syndrome (LEMS) is a neuromuscular disorder, often associated with small cell lung carcinoma (SCLC), which is characterized by reduced quantal release of acetylcholine from the motor nerve terminals. LAMBERT-EATON MYASTHENIC SYNDROME: The Lambert-Eaton Myasthenic Syndrome (LEMS) is characterized by proximal muscle weakness initially affecting gait, autonomic symptoms (dry mouth, constipation, erectile failure) and augmentation of strength during initial voluntary activation. Symptomatic treatment of the junctional disorder is based on cholinergic drugs, immunosuppression, immunomodulation and physical therapy useful in case of unsuccessful antineoplastic therapy.