Open AccessGoodpasture's syndrome: Case report
Author(s) -
Biljana Vučković,
Tamara Ilić,
Igor Mitić,
Violeta Knežević,
S Vodopivec,
S Curić
Publication year - 2004
Publication title -
medicinski pregled
Language(s) - English
Resource type - Journals
eISSN - 1820-7383
pISSN - 0025-8105
DOI - 10.2298/mpns0408391v
Subject(s) - medicine , goodpasture's syndrome , plasmapheresis , pulmonary hemorrhage , rapidly progressive glomerulonephritis , hemodialysis , renal biopsy , surgery , renal function , kidney , glomerulonephritis , antibody , immunology , lung
Goodpasture's syndrome is a rare, autoimmune disease characterized by pulmonary hemorrhage, glomerulonephritis and production of anti-GBM (glomerular basement membrane) antibodies. The etiology of this syndrome is still unknown. Goodpasture's syndrome usually starts with pulmonary hemorrhage, which is followed by symptoms of kidney disease. Laboratory findings often include: anemia, microhematuria, proteinuria, increased levels of urea and creatinine and anti-GBM antibodies. Diagnosis of this syndrome can be established by presence of pulmonary hemorrhage, pulmonary radiography, kidney biopsy and positive result of circulating anti-GBM antibodies. Treatment of this syndrome should be initiated as soon as possible using a combination of corticosteroids, cytostatics and plasmapheresis.