Psychiatric adverse effects induced by recombinant interferon alfa in patients with chronic hepatitis C | Zendy

Zorica Nešić | Zendy; Dragan Delić | Zendy; Milica Prostran | Zendy; Radan Stojanović | Zendy; Sonja Vučković | Zendy; Zoran Todorović | Zendy

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Psychiatric adverse effects induced by recombinant interferon alfa in patients with chronic hepatitis C

Author(s) -

Zorica Nešić,

Dragan Delić,

Milica Prostran,

Radan Stojanović,

Sonja Vučković,

Zoran Todorović

Publication year - 2004

Publication title -

medicinski pregled

Language(s) - English

Resource type - Journals

eISSN - 1820-7383

pISSN - 0025-8105

DOI - 10.2298/mpns0406219n

Subject(s) - irritability , medicine , ribavirin , depression (economics) , anxiety , gastroenterology , adverse effect , interferon alfa , psychiatry , mood , insomnia , apathy , hepatitis c , alpha interferon , interferon , disease , hepatitis c virus , immunology , virus , economics , macroeconomics

Hepatitis C virus infection is a slowly progressive chronic disease and the most common cause of chronic liver disease. Presently, interferon alfa based therapies, with or without ribavirin, are standard treatment for chronic hepatitis C virus infection. The most troublesome psychiatric side effects of interferon therapy in our patients are: insomnia, irritability, anxiety, mood changes, short temper, emotional and affective lability, impaired cognitive function, apathy, loss of motivation and the most serious depression with or without suicidal ideas.

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