Heredity of psoriasis | Zendy

D Belić | Zendy; Sonja Ristic-Nikolic | Zendy; Saveta Damjan | Zendy; Iljana Ratkov | Zendy; Matilda Ceke | Zendy

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Heredity of psoriasis

Author(s) -

D Belić,

Sonja Ristic-Nikolic,

Saveta Damjan,

Iljana Ratkov,

Matilda Ceke

Publication year - 2004

Publication title -

medicinski pregled

Language(s) - English

Resource type - Journals

eISSN - 1820-7383

pISSN - 0025-8105

DOI - 10.2298/mpns0404171b

Subject(s) - psoriasis , proband , medicine , heredity , penetrance , genetic predisposition , first degree relatives , disease , epidemiology , family aggregation , family history , dermatology , genetics , phenotype , mutation , gene , biology

Epidemiological studies of twins show that there is a genetic predisposition to psoriasis. Researches conducted so far show that psoriasis is a multifactorial polygenetic disease with reduced gene penetration. They also show that heredity is more significant than the "trigger" factor whose influence is limited to the exchange of phenotypes. Researches in USA, Canada and Europe identified four most important loci (psoriasis susceptibility--1-4). At least one is in MHC (major histocompatibility complex) due to the connection between psoriasis and alleles of human leukocyte antigen (HLA).

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