Open AccessIdentification of anti-HLA-A1 antibodies in a multi-transfused patient: Case report
Author(s) -
Svetlana Vojvodić,
Stevan Popović,
Ivana Urošević
Publication year - 2004
Publication title -
medicinski pregled
Language(s) - English
Resource type - Journals
eISSN - 1820-7383
pISSN - 0025-8105
DOI - 10.2298/mpns0402077v
Subject(s) - medicine , human leukocyte antigen , antibody , immunology , antigen , immunization , isoantibodies , pregnancy , biology , genetics
HLA antibodies develop as a result of alloimmunization to HLA class I and II antigens. Their appearance is associated with frequent blood transfusions, allogeneic tissue and organ transplantation, pregnancy and immunization. It is established that after usage of single dose HLA nonmatched leukocytes, circulating lymphocytotoxic antibodies appear in serum of recipients, 10 to 12 days after alloimmunization.