Open AccessImmune reconstitution following hematopoietic stem cell transplantation, monitoring parameters and new methods of its assessment
Author(s) -
Svetlana Vojvodić
Publication year - 2002
Publication title -
medicinski pregled
Language(s) - English
Resource type - Journals
eISSN - 1820-7383
pISSN - 0025-8105
DOI - 10.2298/mpns0208293v
Subject(s) - immunology , medicine , immune system , elispot , transplantation , hematopoietic stem cell transplantation , antigen , cd8 , t cell , stem cell , minor histocompatibility antigen , human leukocyte antigen , major histocompatibility complex , biology , genetics
Despite engraftment and function of graft after hematopoietic stem cell transplantation severe immune suppression is a characteristics of early posttransplant period. Primary parameters contributing to posttransplant immuno-incompetence include: lack of sustained transfer of donor antigen specific immunity, recapitulation of immunological ontogeny, effect of graft-versus-host disease (GvHD) and its therapy and reduction of the recipient's thymic function.