Immune reconstitution following hematopoietic stem cell transplantation, monitoring parameters and new methods of its assessment | Zendy

Svetlana Vojvodić | Zendy

Open Access

Immune reconstitution following hematopoietic stem cell transplantation, monitoring parameters and new methods of its assessment

Author(s) -

Svetlana Vojvodić

Publication year - 2002

Publication title -

medicinski pregled

Language(s) - English

Resource type - Journals

eISSN - 1820-7383

pISSN - 0025-8105

DOI - 10.2298/mpns0208293v

Subject(s) - immunology , medicine , immune system , elispot , transplantation , hematopoietic stem cell transplantation , antigen , cd8 , t cell , stem cell , minor histocompatibility antigen , human leukocyte antigen , major histocompatibility complex , biology , genetics

Despite engraftment and function of graft after hematopoietic stem cell transplantation severe immune suppression is a characteristics of early posttransplant period. Primary parameters contributing to posttransplant immuno-incompetence include: lack of sustained transfer of donor antigen specific immunity, recapitulation of immunological ontogeny, effect of graft-versus-host disease (GvHD) and its therapy and reduction of the recipient's thymic function.

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