Open AccessSynthesis and physicochemical characterization of Arabic gum microgels modified with methacrylic acid as potential drug carriers
Author(s) -
Sani Ibrahim,
Misni Misran,
Yin Yin Teo
Publication year - 2022
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc210909015d
Subject(s) - zeta potential , dynamic light scattering , chemical engineering , methacrylic acid , materials science , differential scanning calorimetry , drug delivery , swelling , emulsion polymerization , particle size , drug carrier , polymer chemistry , polymer , chemistry , nuclear chemistry , polymerization , nanoparticle , nanotechnology , composite material , physics , engineering , thermodynamics
Microgels of carbohydrate polymers are non-toxic and biocompatible that can readily be used in applications such as drug delivery, medicine, and pharmacy. In this work, Arabic gum (AG) microgels and methacrylic acid modified Arabic gum microgels (AGMAA) were synthesized via the water in oil emulsion polymerization technique using Tween 20 as the surfactant and hexane as the solvent. The microgels were characterized using various physico-chemical methods such as Fourier transform infrared spectroscopy, thermal stability using differential scanning calorimetry, diffraction pattern analysis using X-Ray diffraction, morphology observation using field emission scanning electron microscopy and dynamic light scattering was used to analyze the size and zeta potential. The rate of deformation was higher in the AG microgels com-pared to the AGMAA microgels. The particle size and zeta potential of the AGMAA microgel were found to be larger and more negative than AG microgel, respectively. The particle size and zeta potentials of the microgels were found to be dependent on the amount of methacrylic acid as the modifying agent. The microgels were encapsulated with doxorubicin through the swelling method and the in vitro release was studied in mediums with pH values of 4.2 and 7.4. The results suggest the potentials of these microgels for drugs delivery.