Open AccessSynthesis, characterization, antimicrobial screening and cytotoxic properties of Cu(II) and Zn(II) complexes with bidentate hydroxylated 1,3-diaryl-2-propene-1-ones ligand
Author(s) -
Pravinkumar Patil,
Sainath Zangade
Publication year - 2021
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc200901068z
Subject(s) - denticity , chemistry , antimicrobial , metal , deprotonation , stereochemistry , ligand (biochemistry) , metal ions in aqueous solution , medicinal chemistry , proton nmr , organic chemistry , ion , biochemistry , receptor
A series of binary metal complexes (halo, hydroxyl and methoxy substituted bis(2-(E)acryloyl)naphthalen-1-yl)oxy)Cu(II) and Zn(II) (C1? ?C10)) of Cu2+ and Zn2+ ions derived from bi-coordinated hydroxylated 1,3- -diaryl-2-propene-1-ones were synthesized. The newly synthesized metal complexes were structurally determined by FT-IR, 1H-NMR, 13C-NMR, ESR spectral, XRD and TGA analyses. The FT-IR and ESR studies demonstrated that interactions between metal ions with ligands occur through carbonyl oxygen and deprotonated hydroxyl oxygen and correspond to square-planar geometry for all complexes. The metal complexes were screened in-vitro and evaluated for their antimicrobial and cytotoxic activities. The complexes C1 and C4 showed significant antimicrobial activity while the remaining complexes showed moderate antimicrobial activity against the tested pathogens. The complexes were evaluated for cytotoxic activity against the organism Artemia salina. Complexes C2?C5 exhibited LC50 values of 630.45, 969.99, 921.94 and 918.41 ?M mL-1, respectively. Furthermore, the complexes were evaluated for their anticancer activity against the liver cancer cell line Hep G2 in comparison with the 5-fluorouracil standard. Complex C5 showed a significant IC50 value of 58.94 ?g mL-1. Therefore, the present study is useful for the development of a new class of antimicrobial and anticancer agents.