Open AccessContinuous flow synthesis of some 6- and 1,6-substituted 3-cyano-4-methyl-2-pyridones
Author(s) -
Julijana Tadić,
Marina Mihajlović,
Milena Jovanović,
Dušan Ž. Mijin
Publication year - 2019
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc180703092t
Subject(s) - microreactor , yield (engineering) , continuous flow , chemistry , analytical chemistry (journal) , combinatorial chemistry , organic chemistry , materials science , catalysis , physics , mechanics , metallurgy
In this study, six 6- and 1,6-substituted-3-cyano-4-methyl-2-pyridones were synthesized in a continuous flow microreactor system. The syntheses were realized at room temperature and the obtained results were compared to those achieved within classical syntheses. In order to optimize the continuous flow syntheses and increase the yield of the products, the retention time in the microreactor was varied by changing the flow rates of the reactant solutions. Furthermore, the reaction was optimized for 3-cyano-4,6-dimethyl-2- -pyridone and 3-cyano-6-hydroxy-4-methyl-2-pyridone, which are comercially important in the pharmaceutical and dye industries. Both 2-pyridones were obtained in satisfactory yield of circa 60 % in less than 10 min. The resulting compounds were characterized by their melting points, FT-IR, 1H-NMR and UV?Vis spectra. The efficiency of the presented method for the synthesis of 2-pyridone-based molecules has promising potential for industrial production.