Synthesis, antioxidant and antimicrobial activity of carbohydrazones | Zendy

Aleksandra R. Božić | Zendy; Nenad R. Filipović | Zendy; Ireovaković | Zendy; Snežana Bjelogrlić | Zendy; Jasmiikolić | Zendy; Saša Drmanić | Zendy; Аleksandar Marinković | Zendy

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Synthesis, antioxidant and antimicrobial activity of carbohydrazones

Author(s) -

Aleksandra R. Božić,

Nenad R. Filipović,

Ireovaković,

Snežana Bjelogrlić,

Jasmiikolić,

Saša Drmanić,

Аleksandar Marinković

Publication year - 2017

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc161220045b

Subject(s) - antioxidant , chemistry , antimicrobial , isomerization , bacteria , molecule , in vitro , gram , stereochemistry , organic chemistry , combinatorial chemistry , biochemistry , catalysis , biology , genetics

Fourteen mono- and bis-carbohydrazone ligands have been synthesized and characterized. Antioxidant activity of the substances was investigated together with possible (E)/(Z) isomerization, and explained on the most active antioxidant compound 4 in various dimethyl sulphoxide–water mixtures. The addition of water to the system was involved in the formation of hydrated molecules which was confirmed in NMR after the addition of D2O. The ligands were tested in vitro against Gram-positive and Gram-negative bacteria and fungi, and their activity was discussed in relation to the structure of investigated carbohydrazone. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 172013

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