Open AccessSynthesis, antioxidant and antimicrobial activity of carbohydrazones
Author(s) -
Aleksandra Božić,
Nenad R. Filipović,
Ireovaković,
Snežana K. Bjelogrlić,
Jasmina B. Nikolić,
Saša Ž. Drmanić,
Aleksandar D. Marinković
Publication year - 2017
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc161220045b
Subject(s) - antioxidant , antimicrobial , chemistry , isomerization , bacteria , molecule , in vitro , gram , organic chemistry , combinatorial chemistry , stereochemistry , biochemistry , catalysis , biology , genetics
Fourteen mono- and bis-carbohydrazone ligands have been synthesized and characterized. Antioxidant activity of the substances was investigated together with possible (E)/(Z) isomerization, and explained on the most active antioxidant compound 4 in various dimethyl sulphoxide–water mixtures. The addition of water to the system was involved in the formation of hydrated molecules which was confirmed in NMR after the addition of D2O. The ligands were tested in vitro against Gram-positive and Gram-negative bacteria and fungi, and their activity was discussed in relation to the structure of investigated carbohydrazone. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 172013