Open AccessOne-pot synthesis of carbazole based 3-hydroxy-4H-chromen-4-ones by modified Algar-Flynn-Oyamada reaction and their antimicrobial activity
Author(s) -
Dongamanti Ashok,
S. Ravi,
Lakshmi Boppana,
Arram Ganesh
Publication year - 2015
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc141203051a
Subject(s) - antimicrobial , bacillus subtilis , aspergillus flavus , chemistry , carbazole , fusarium oxysporum , klebsiella pneumoniae , carbon 13 nmr , escherichia coli , proton nmr , organic chemistry , flavonols , nuclear chemistry , bacteria , biochemistry , biology , food science , genetics , botany , flavonoid , gene , antioxidant
A new series of 2-(9-ethyl-9H-carbazol-3-yl)-3-hydroxy-4Hchromen-4-ones have been synthesized from substituted 2-hydroxy acetophenones and 9-ethyl-9H-carbazole-3-carbaldehyde using NaOH and H2O2 by modified Algar-Flynn-Oyamada reaction. In this method flavonols are synthesized without isolating chalcones in good yields (70-82%). The structures of the compounds were established on the basis of 1H-NMR, 13CNMR, FT-IR and mass spectral and analytical data. All the compounds were evaluated for their antimicrobial activity against bacteria such as Staphylococus aureus, Bacillus subtilis, Escherichia coli and Klebsiella pneumoniae as well as fungi such as Aspergillus flavus and Fusarium oxysporum