Open AccessSynthesis of 2-azetidinones substituted quinoline derivative
Author(s) -
C Uday Mashelkar,
Satadru Jha,
U Beena Mashelkar
Publication year - 2013
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc120617081m
Subject(s) - quinoline , acetanilide , chemistry , toluene , schiff base , derivative (finance) , base (topology) , organic chemistry , medicinal chemistry , combinatorial chemistry , polymer chemistry , mathematics , mathematical analysis , financial economics , economics
Acetanilide is converted into 2-chloro-3-formyl quinoline by reacting with DMF-POCl3 at 80-90ºC and then condensed with aromatic primary amines to give Schiff bases (3a-3c). These Schiff bases are then reacted with acid chlorides in the presence of base in toluene to give 1, 3, 4-substituted 2-azetidinones