Open AccessSynthesis of some novel 7-(1H-benzimidazol-2-ylazo)-1,3-dimethyl-6,8-disubstituted-1,5-dihydro pyrimido[4,5-b] [1,4] diazepine-2,4-diones as potential antianxiety agents
Author(s) -
Kapil Sharma,
P. K. Jain
Publication year - 2013
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc120409082s
Subject(s) - diazepine , chemistry , solvent , proton nmr , ionic liquid , carbon 13 nmr , combinatorial chemistry , organic chemistry , medicinal chemistry , ring (chemistry) , catalysis
An efficient and mild method for the synthesis of some novel 7-(1H-Benzimidazol-2-ylazo)-1,3-dimethyl-6,8-disubstituted-1,5-dihydropyrimi-do[4,5-b] [1,4] diazepine-2,4-diones in water has been developed. This method is a good option to obtain the title compounds in quantitative yields in a simple and inexpensive way. Further, -NH of the title compounds was replaced by various substituents in an ionic liquid, [bmim]PF6, a recyclable and environmentally benign solvent. Synthesized compounds were characterized by analytical and spectral (IR, 1H NMR, 13C NMR and Fmass) data and have been screened for their antianxiety activity in mice