Open AccessEffects of solvent and structure on the reactivity of 2-substituted nicotinic acids with diazodiphenylmethane in aprotic solvents
Author(s) -
Saša Ž. Drmanić,
Jasmina B. Nikolić,
Bratislav Ž. Jovanović
Publication year - 2012
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc120223019d
Subject(s) - substituent , chemistry , solvatochromism , reaction rate constant , solvent , reactivity (psychology) , solvent effects , taft equation , hammett equation , computational chemistry , nicotinic agonist , medicinal chemistry , organic chemistry , kinetics , medicine , biochemistry , physics , alternative medicine , receptor , pathology , quantum mechanics
The rate constants for the reactions of diazodiphenylmethane (DDM) with 2-substituted nicotinic acids in nine aprotic solvents at 30°C were determined. The obtained second order rate constants in aprotic solvents, were correlated using the Kamlet-Taft solvatochromic equation in the complete form: log k = log k0 + s