Open AccessL-proline catalyzed efficient and clean synthesis of polysubstituted benzenes in the ionic liquid [bmim]PF6
Author(s) -
Shubha Jain,
Balwant S. Keshwal,
Deepika Rajguru
Publication year - 2012
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc111211067j
Subject(s) - ionic liquid , chemistry , catalysis , proline , nucleophile , medicinal chemistry , organic chemistry , combinatorial chemistry , amino acid , biochemistry
A clean and efficient synthesis of polysubstituted benzenes has been developed via sequential vinylogous Michael addition and nucleophilic cyclization reactions of arylethylidenemalonodinitriles with arylidenemalo-nodinitriles in ionic liquid [bmim]PF6 catalyzed by L-proline