Synthesis of 2-azetidinones substituted coumarin derivative | Zendy

Uday C. Mashelkar | Zendy; Mukesh S. Jha | Zendy; Beena U. Mashelkar | Zendy

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Synthesis of 2-azetidinones substituted coumarin derivative

Author(s) -

Uday C. Mashelkar,

Mukesh S. Jha,

Beena U. Mashelkar

Publication year - 2012

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc111024045m

Subject(s) - chemistry , ethyl acetoacetate , toluene , coumarin , schiff base , derivative (finance) , medicinal chemistry , organic chemistry , base (topology) , polymer chemistry , catalysis , mathematical analysis , mathematics , financial economics , economics

α-Naphthol is converted into 4-methylbenzo[h]chromen-2-one by reacting with ethyl acetoacetate in the presence of bismuth trichloride which is then oxidized to 2-oxo-2H-benzo[h]chromene-4-carbaldehyde and then condensed with aromatic primary amines to give Schiff bases (3a-3d). These Schiff bases are then reacted with acid chlorides in the presence of base in toluene to give 1, 3, 4-substituted 2-azetidinones

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