Synthesis of 2-oxo-azetidine derivatives of 2-amino thiazole and their biological activity | Zendy

Pushkal Samadhiya | Zendy; Ritu Sharma | Zendy; S. K. Srivastava | Zendy; Savitri Srivastava | Zendy

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Synthesis of 2-oxo-azetidine derivatives of 2-amino thiazole and their biological activity

Author(s) -

Pushkal Samadhiya,

Ritu Sharma,

S. K. Srivastava,

Savitri Srivastava

Publication year - 2012

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc110616002s

Subject(s) - thiazole , azetidine , chemistry , antifungal , proton nmr , carbon 13 nmr , antibacterial activity , bacteria , organic chemistry , elemental analysis , nuclear chemistry , stereochemistry , combinatorial chemistry , microbiology and biotechnology , biology , genetics

A new series of N-[2-(2-aminothiazolyl)ethyl]-4-(substitutedphenyl)- 3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-m) have been synthesized from 2-aminothiazole as a starting material. The structure of all the synthesized compounds were confirmed by chemical and spectral analyses such as IR, 1H NMR, 13C NMR and FAB-Mass. All the final synthesized compounds 4(a-m) were screened for their antibacterial and antifungal activities against some selected bacteria and fungi and antitubercular activity screened against M. tuberculosis with their MIC value. Antiinflammatory activity screened against albino rats (either sex) and gave acceptable results

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