Open AccessSynthesis of 2-oxo-azetidine derivatives of 2-amino thiazole and their biological activity
Author(s) -
Pushkal Samadhiya,
Ritu Sharma,
Kripa Srivastava,
Dhiraj Srivastava
Publication year - 2012
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc110616002s
Subject(s) - thiazole , azetidine , chemistry , antifungal , proton nmr , carbon 13 nmr , antibacterial activity , bacteria , organic chemistry , elemental analysis , nuclear chemistry , stereochemistry , combinatorial chemistry , microbiology and biotechnology , biology , genetics
A new series of N-[2-(2-aminothiazolyl)ethyl]-4-(substitutedphenyl)- 3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-m) have been synthesized from 2-aminothiazole as a starting material. The structure of all the synthesized compounds were confirmed by chemical and spectral analyses such as IR, 1H NMR, 13C NMR and FAB-Mass. All the final synthesized compounds 4(a-m) were screened for their antibacterial and antifungal activities against some selected bacteria and fungi and antitubercular activity screened against M. tuberculosis with their MIC value. Antiinflammatory activity screened against albino rats (either sex) and gave acceptable results