Synthesis of new derivatives of 1-(3-amino-phenyl)-4- benzoyl-5-phenyl-1h-pyrazole-3-carboxylic acid | Zendy

Rahmi Kasımoğulları | Zendy; Belma Zengin Kurt | Zendy; Makbule Maden | Zendy; Samet Mert | Zendy; Cavit Kazaz | Zendy

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Synthesis of new derivatives of 1-(3-amino-phenyl)-4- benzoyl-5-phenyl-1h-pyrazole-3-carboxylic acid

Author(s) -

Rahmi Kasımoğulları,

Belma Zengin Kurt,

Makbule Maden,

Samet Mert,

Cavit Kazaz

Publication year - 2010

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc101018135k

Subject(s) - pyrazole , hydrazine (antidepressant) , chemistry , phenol , reagent , hydrate , elemental analysis , carboxylic acid , carbon 13 nmr , medicinal chemistry , proton nmr , organic chemistry , chromatography

4-Benzoyl-1-(3-aminophenyl)-5-phenyl-1H-pyrazole-3- carboxylic acid (1) was synthesized according to the literature.1 2-(3- Aminophenyl)-3,4-diphenyl-2H-pyrazolo[3,4-d]pyridazin-7(6H)-one (5) was obtained by the cyclocondensation reaction of 1 with hydrazine hydrate. New pyrazole derivatives of compounds 1 and 5 were synthesized by their reaction with ?-diketones, ?-ketoesters, ?-naphthol, phenol and various other reagents. The structures of the synthesized compounds were characterized by 1H-NMR, 13C-NMR, IR and Mass spectroscopy, as well as elemental analysis.

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