Open AccessSynthesis of new derivatives of 1-(3-amino-phenyl)-4- benzoyl-5-phenyl-1h-pyrazole-3-carboxylic acid
Author(s) -
Rahmi Kasımoğulları,
Belma Zengin,
Makbule Maden,
Samet Mert,
Cavit Kazaz
Publication year - 2010
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc101018135k
Subject(s) - pyrazole , hydrazine (antidepressant) , chemistry , phenol , reagent , hydrate , elemental analysis , carboxylic acid , carbon 13 nmr , medicinal chemistry , proton nmr , organic chemistry , chromatography
4-Benzoyl-1-(3-aminophenyl)-5-phenyl-1H-pyrazole-3- carboxylic acid (1) was synthesized according to the literature.1 2-(3- Aminophenyl)-3,4-diphenyl-2H-pyrazolo[3,4-d]pyridazin-7(6H)-one (5) was obtained by the cyclocondensation reaction of 1 with hydrazine hydrate. New pyrazole derivatives of compounds 1 and 5 were synthesized by their reaction with ?-diketones, ?-ketoesters, ?-naphthol, phenol and various other reagents. The structures of the synthesized compounds were characterized by 1H-NMR, 13C-NMR, IR and Mass spectroscopy, as well as elemental analysis.