Open AccessFacile syntheses of Mannich bases of 3-[p-(5'-aryl-pyrazolin-3'-yl)]-phenylsydnones, as anti-tubercular and anti-microbial agents, under ionic liquid/TBAB catalytic conditions
Author(s) -
Tasneem Taj,
Ravindra R. Kamble,
Tegginamath Gireesh,
K Ravindra Hunnur
Publication year - 2011
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc100708085t
Subject(s) - ionic liquid , chemistry , catalysis , antimicrobial , antifungal , methylene , elemental analysis , aryl , combinatorial chemistry , ionic bonding , derivative (finance) , mannich reaction , organic chemistry , mannich base , nuclear chemistry , microbiology and biotechnology , alkyl , ion , financial economics , economics , biology
% MIC % antitubercular activityKR nemaNovel methylene bridged Mannich bases 2(a-j) were synthesized in good to excellent yields from the pyrazoline derivative (1) using various primary/secondary amines, 37 % formalin in presence of ionic liquids/TBas catalyst. The structures of the newly synthesized compounds were confirmed by IR, 1H- and 13C-NMR and GC-MS spectroscopy, as well as elemental analysis. The title compounds were screened for their anti-tubercular and antimicrobial activities. Some of the compounds exhibited very good anti-tubercular, antifungal and antibacterial activities.