Facile syntheses of Mannich bases of 3-[p-(5'-aryl-pyrazolin-3'-yl)]-phenylsydnones, as anti-tubercular and anti-microbial agents, under ionic liquid/TBAB catalytic conditions | Zendy

Tasneem Taj | Zendy; Ravindra R. Kamble | Zendy; Tegginamath Gireesh | Zendy; Ravindra Hunnur | Zendy

Open Access

Facile syntheses of Mannich bases of 3-[p-(5'-aryl-pyrazolin-3'-yl)]-phenylsydnones, as anti-tubercular and anti-microbial agents, under ionic liquid/TBAB catalytic conditions

Author(s) -

Tasneem Taj,

Ravindra R. Kamble,

Tegginamath Gireesh,

Ravindra Hunnur

Publication year - 2011

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc100708085t

Subject(s) - ionic liquid , chemistry , catalysis , antimicrobial , antifungal , methylene , elemental analysis , aryl , combinatorial chemistry , ionic bonding , derivative (finance) , mannich reaction , organic chemistry , mannich base , nuclear chemistry , microbiology and biotechnology , alkyl , ion , financial economics , economics , biology

% MIC % antitubercular activityKR nemaNovel methylene bridged Mannich bases 2(a-j) were synthesized in good to excellent yields from the pyrazoline derivative (1) using various primary/secondary amines, 37 % formalin in presence of ionic liquids/TBas catalyst. The structures of the newly synthesized compounds were confirmed by IR, 1H- and 13C-NMR and GC-MS spectroscopy, as well as elemental analysis. The title compounds were screened for their anti-tubercular and antimicrobial activities. Some of the compounds exhibited very good anti-tubercular, antifungal and antibacterial activities.

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