Open AccessSynthesis, characterization and antimicrobial activity of (5- bromo-5-nitro-2-oxido-1,3,2-dioxaphosphinan-2-yl)amino acid esters
Author(s) -
P. Santhipriya,
Radha Rani Chinthaparthi,
N. J. Reddy,
C H Syama Sundar,
C. Suresh Reddy
Publication year - 2011
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc100520059s
Subject(s) - triethylamine , chemistry , tetrahydrofuran , nitro , antimicrobial , antifungal , organic chemistry , medicinal chemistry , microbiology and biotechnology , alkyl , solvent , biology
Synthesis of a new series of (5-bromo-5-nitro-2-oxido-1,3,2- dioxaphosphinan-2-yl)amino acid esters (3a-l) was accomplished via a two step process, which involves the prior preparation of the monochloride intermediate (2) and its subsequent reaction with the amino acid esters in dry tetrahydrofuran in the presence of triethylamine at reflux temperature. The title compounds (3a-l) structures were established by analytical, IR, 1H-, 13C- and 31P-NMR, and mass spectral data. They exhibited significant antibacterial and antifungal activity.