Open AccessAntibacterial activity of cobalt(II) complexes with some benzimidazole derivatives
Author(s) -
Sanja Podunavac-Kuzmаnоvić,
Vukadin M. Leovac,
Dragoš Cvetković
Publication year - 2008
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc0812153p
Subject(s) - bacillus cereus , antibacterial activity , benzimidazole , bacteria , chemistry , gram positive bacteria , in vitro , cobalt , sarcina , staphylococcus aureus , gram negative bacteria , pseudomonas aeruginosa , minimum inhibitory concentration , microbiology and biotechnology , stereochemistry , antimicrobial , biochemistry , escherichia coli , biology , organic chemistry , genetics , gene
The antibacterial activities of cobalt(II) complexes with two series of benzimidazoles were evaluated in vitro against three Gram-positive bacterial strains (Bacillus cereus, Staphylococcus aureus, and Sarcina lutea) and one Gram-negative isolate (Pseudomonas aeruginosa). The minimum inhibitory concentration was determined for all the complexes. The majority of the investtigated complexes displayed in vitro inhibitory activity against very persistent bacteria. They were found to be more active against Gram-positive than Gram-negative bacteria. It may be concluded that the antibacterial activity of the compounds is related to the cell wall structure of the tested bacteria. Comparing the inhibitory activities of the tested complexes, it was found that the 1-substituted- -2-aminobenzimidazole derivatives were more active than complexes of 1-substituted- 2-amino-5,6-dimethylbenzimidazoles. The effect of chemical structure on the antibacterial activity is discussed.