Open AccessBenzylation of N-phenyl-2-phenylacetamide under microwave irradiation
Author(s) -
Dušan Ž. Mijin,
Masa Prascevic,
Slobodan Petrović
Publication year - 2008
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc0810945m
Subject(s) - potassium hydroxide , chemistry , microwave irradiation , alkylation , irradiation , catalysis , benzyl chloride , chloride , microwave , potassium , solvent , nuclear chemistry , hydroxide , organic chemistry , inorganic chemistry , physics , quantum mechanics , nuclear physics
N-Phenyl-2-phenylacetamide was alkylated with benzyl chloride in the presence of powdered potassium hydroxide under microwave irradiation in a solvent-free system. The reactions were also performed in the presence of phase-transfer catalysts. The formation of N-, O- and C-products of alkylation was followed by gas chromatography. The N-product was found to be the main product under microwave irradiation. The O-product was obtained in higher yields when an excess of base and benzyl chloride was used.