Benzylation of N-phenyl-2-phenylacetamide under microwave irradiation | Zendy

Dušan Mijin | Zendy; Masa Prascevic | Zendy; Slobodan Petrović | Zendy

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Benzylation of N-phenyl-2-phenylacetamide under microwave irradiation

Author(s) -

Dušan Mijin,

Masa Prascevic,

Slobodan Petrović

Publication year - 2008

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0810945m

Subject(s) - potassium hydroxide , chemistry , microwave irradiation , alkylation , irradiation , catalysis , benzyl chloride , chloride , microwave , potassium , solvent , nuclear chemistry , hydroxide , organic chemistry , inorganic chemistry , physics , quantum mechanics , nuclear physics

N-Phenyl-2-phenylacetamide was alkylated with benzyl chloride in the presence of powdered potassium hydroxide under microwave irradiation in a solvent-free system. The reactions were also performed in the presence of phase-transfer catalysts. The formation of N-, O- and C-products of alkylation was followed by gas chromatography. The N-product was found to be the main product under microwave irradiation. The O-product was obtained in higher yields when an excess of base and benzyl chloride was used.

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