Open AccessA green process for the preparation of 11-{4-[2-(2-hydroxyethoxy) ethyl]-1-piperazinyl}dibenzo[b,f][1,4]thiazepine
Author(s) -
Ganesh D. Mahale,
Ashok Kumar,
Dalbir Singh,
A.V. Ramaswamy,
Suresh B. Waghmode
Publication year - 2008
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc0804385m
Subject(s) - chemistry , catalysis , medicinal chemistry , halide , solvent , salt (chemistry) , ethanol , green chemistry , combinatorial chemistry , organic chemistry , reaction mechanism
A green process for the synthesis of 11-{4-[2-(2-hydroxyethoxy)ethyl]- 1-piperazinyl}dibenzo[b,f][1,4]thiazepine by the reaction of 11-(1-piperazinyl) dibenzo[b,f][1,4]thiazepine or its dihydrochloride salt with 2-(2-chloroethoxy) ethanol in the presence of an inorganic base and water is reported (conversion 99.9 % in a short time and without any impurities). The metal halides and phase transfer catalyst increase the rate of reaction, especially in water as the solvent.