A green process for the preparation of 11-{4-[2-(2-hydroxyethoxy) ethyl]-1-piperazinyl}dibenzo[b,f][1,4]thiazepine | Zendy

Ganesh Mahale | Zendy; Ashok Kumar | Zendy; Dharmendra Singh | Zendy; A.V. Ramaswamy | Zendy; Suresh B. Waghmode | Zendy

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A green process for the preparation of 11-{4-[2-(2-hydroxyethoxy) ethyl]-1-piperazinyl}dibenzo[b,f][1,4]thiazepine

Author(s) -

Ganesh Mahale,

Ashok Kumar,

Dharmendra Singh,

A.V. Ramaswamy,

Suresh B. Waghmode

Publication year - 2008

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0804385m

Subject(s) - chemistry , catalysis , halide , solvent , medicinal chemistry , salt (chemistry) , ethanol , combinatorial chemistry , organic chemistry

A green process for the synthesis of 11-{4-[2-(2-hydroxyethoxy)ethyl]- 1-piperazinyl}dibenzo[b,f][1,4]thiazepine by the reaction of 11-(1-piperazinyl) dibenzo[b,f][1,4]thiazepine or its dihydrochloride salt with 2-(2-chloroethoxy) ethanol in the presence of an inorganic base and water is reported (conversion 99.9 % in a short time and without any impurities). The metal halides and phase transfer catalyst increase the rate of reaction, especially in water as the solvent.

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