Open AccessAntibacterial evaluation of some benzimidazole derivatives and their zinc(II) complexes
Author(s) -
Sanja Podunavac-Kuzmаnоvić,
Dragoš Cvetković
Publication year - 2007
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc0705459p
Subject(s) - benzimidazole , chemistry , bacillus cereus , zinc , antimicrobial , staphylococcus aureus , antibacterial activity , pseudomonas aeruginosa , in vitro , bacteria , sarcina , gram positive bacteria , minimum inhibitory concentration , nuclear chemistry , microbiology and biotechnology , biochemistry , organic chemistry , biology , genetics
Zinc(II) chloride was reacted with some 1-benzylbenzimidazole derivatives (L) to give complexes of the formula ZnL2Cl2. All the ligands and their zinc(II) complexes were evaluated for their in vitro antibacterial activity against Pseudomonas aeruginosa, Bacillus cereus, Staphylococcus aureus and Sarcina lutea. Themajority of the investigated compounds displayed in vitro antimicrobial activity against very persistent microorganisms. It was found that all the tested compounds were more active against gram-positive than gram-negative bacteria. The minimum inhibitory concentration (MIC) was determined for all ligands and their complexes. The effect of the structure of the ligands and complexes on the antimicrobial activity is discussed. The complexes were found to be more toxic than the ligands.