Open AccessSynthesis of new 3-(2-aminothiazol-4-yl)-4-hydroxy-2H-chromen-2-one derivatives
Author(s) -
Slobodan Sukdolak,
Nenad Vuković,
Slavica Solujić,
M. Milosev,
N. Manojlović,
Lj. Krstić
Publication year - 2006
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc0606581s
Subject(s) - thiourea , chemistry , ethanol , yield (engineering) , elemental analysis , proton nmr , organic chemistry , carbon 13 nmr , metallurgy , materials science
Aminothiazole derivatives of 4-hydroxy-2H-chromen-2-one were prepared by the Hantzsch reaction1 using 3-(2-bromoacetyl)-4-hydroxy-2H-chromen-2-one and thiourea derivatives. Starting compound for this synthesis 3-(2-bromoacetyl)-4-hydroxy- 2H-chromen-2-one (1) was prepared previously.2 Also, for this synthesis we used thiourea derivatives (2a-j) as compounds which possess groups with biological activity. Reactions are carried out in refluxing ethanol for a period of 30 - 45 min. Final products (3a-j) are obtained in a high yield. Chemical structure of the obtained compounds was confirmed by elemental and structural analysis (IR and 1H NMR spectroscopy).