Open AccessA regioselective alkylation at the C-6 hydroxyl group of erythromycin A-oxime derivatives
Author(s) -
Hosang Master,
Singh Dharmendra
Publication year - 2005
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc0510147m
Subject(s) - regioselectivity , oxime , chemistry , alkylation , erythromycin , group (periodic table) , substrate (aquarium) , medicinal chemistry , organic chemistry , antibiotics , catalysis , biochemistry , oceanography , geology
Erythromycin A contains five hydroxyl groups. The regioselective alkylation at the C-6 hydroxyl group was achieved to an extent of more than 97 % when a 9-O-substituted erythromycin A-9-oxime was employed as the substrate.