Open AccessAlkylation of N-substituted 2-phenylacetamides: Benzylation of N-(4-chlorophenyl)-2-phenylacetamide
Author(s) -
Dušan Ž. Mijin,
Vida D. Jankovic,
Slobodan Petrović
Publication year - 2004
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc0402085m
Subject(s) - chemistry , potassium hydroxide , alkylation , benzyl chloride , toluene , reactivity (psychology) , catalysis , solvent , amide , potassium , organic chemistry , hydroxide , chloride , medicine , alternative medicine , pathology
Benzylation of N-(4-chlorophenyl)-2-phenylacetamidewith benzyl chloride in the presence of powdered potassium hydroxide under various reaction conditions was performed in order to establish the possible reaction products. Different temperatures and ratios of reactants and solvents were used. The reactions were also carried out in the presence of different phase-transfer catalysts in toluene as a solvent. The formation of the reaction products was followed using gas chromatography. On the basis of the obtained results, the reactivity and the orientation in the alkylation reaction of the investigated amide is discussed.