Protolytic equlibria of bromazepam | Zendy

Lidija B. Pfendt | Zendy; Gordana Popović | Zendy; Tatjana Damjanović | Zendy; Dušan Sladić | Zendy

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Protolytic equlibria of bromazepam

Author(s) -

Lidija B. Pfendt,

Gordana Popović,

Tatjana Damjanović,

Dušan Sladić

Publication year - 2002

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0203187p

Subject(s) - bromazepam , chemistry , protonation , ionic strength , pyridine , homogeneous , ionic liquid , equilibrium constant , ionic bonding , inorganic chemistry , aqueous solution , medicinal chemistry , ion , organic chemistry , thermodynamics , catalysis , biochemistry , physics , receptor , benzodiazepine

The protolytic equilibria of bromazepam, an ampholyte sparingly soluble in water, in homogeneous and heterogeneous systems were studied in the pH range 0?14 at 25?C and at ionic strength of 0.1 mol/dm3 (NaCl). On the basis of 13C-NMR spectra, the protonation site was predicted ? in acidic media the pyridine nitrogen of bormazepam is protonated. The acidity constants of bromazepam were determined spectrophotometrically (pKa1 2.83 and pKa2 11.60) and potentiometrically (pKa1 2.99). In the heterogeneous system the following equilibrium constants were determined: Ks0 =[HA]?(pKs0 3.44), Ks1 =[H2A+]/[H3O+](pKs1 0.61), and Ks2 =[A-][H3O+](pKs2 15.04).

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