Spectrophotometric determination of fluocortolone in tablets using 1,4-dihydrazinophthalazine | Zendy

Olivera Čudina | Zendy; Sote Vladimirov | Zendy; D. ŽivanovStakić | Zendy; Danica Agbaba | Zendy

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Spectrophotometric determination of fluocortolone in tablets using 1,4-dihydrazinophthalazine

Author(s) -

Olivera Čudina,

Sote Vladimirov,

D. ŽivanovStakić,

Danica Agbaba

Publication year - 2000

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0009645c

Subject(s) - hydrazone , reagent , detection limit , chemistry , chromatography , solvent , organic chemistry

The proposed method for the determination of fluocortolone is based on the formation of a stable, yellow coloured hydrazone product with 1,4-dihydrazinophthalazine as the reagent. Heating at 85?C for 2 h was found to be necessary to ensure optimal hydrazone formation in acidified 1-propanol as the solvent. The detection limit was 1.2 ?g/ml. This method when applied for the determination of fluocortolone in pharmaceutical formulations gave precise and reproducible results.

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