Open AccessThe crystal structure of 14-0x0-13,14-seco-5α-cholest-13(18)-en-3β-yl acetate and the assignment of the configuration of its acetoxy derivatives
Author(s) -
Bjelaković,
JeanPaul Declercq,
VD Pavlovic,
Lj. Lorenć,
Bernard Tinant
Publication year - 2000
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc0008541b
Subject(s) - chemistry , fragmentation (computing) , crystal structure , stereochemistry , medicinal chemistry , oxidative phosphorylation , crystallography , biochemistry , computer science , operating system
The crystal structure of 14-oxo-13,14-seco-5?-cholest-13(18)-en-3?-yl acetate (2), obtained (in addition to the (E)-?l2-isomer 3) by oxidative fragmentation of the C(13)-C(14) bond of 14?-hydroxy-5?-cholestan-3?-yl acetate (1), was determined by X-ray analysis. In addition, the configurations of the acetoxy derivatives 4-6, formed by the thermal lead tetraacetate oxidation of 1, were deduced from the relevant 1?-NMR parameters.