
Otosclerosis: Pathology of the local focus and perilymph
Author(s) -
B Ljiljana Janosevic,
Vojko Djukić,
B Slobodanka Janosevic,
Vladimir Nešić,
Zoran Dudvarski
Publication year - 2003
Publication title -
jugoslovenska medicinska biohemija
Language(s) - English
Resource type - Journals
eISSN - 1452-8193
pISSN - 0354-3447
DOI - 10.2298/jmh0304265j
Subject(s) - otosclerosis , osteoid , perilymph , pathology , biology , medicine , anatomy , inner ear , audiology
Data from numerous pathohistological, histochemical, immunohistochemical and biochemical studies of the otosclerotic tissue in the otic capsule are reviewed and correlated systematically in order to get more complete insight of the local cellular and molecular events in otosclerosis and to derive the basic knowledge from them. The following parameters are focused: sites and distribution of the otosclerotic foci, classification of the local events in otosclerosis, active and inactive otosclerotic foci, osteoid cells, enzyme activity of the otosclerotic foci and perilymph, components of the bone inorganic constituents and matrix. Characteristic morphologic changes and microscopic appearance of the otosclerotic foci are defined as well as the metabolic processes and enzyme disbalances of the disorder with respect to the phase of the otosclerotic bone resorption and formation. The authors specially stress the necessity of constant monitoring and critical evaluation of both the research data and the general concepts in the multifactorial field of otosclerosis.