Open AccessEdible mycorrhizal species Lactarius controversus Pers. 1800 as a source of antioxidant and cytotoxic agents
Author(s) -
Aleksandra Novaković,
Maja Karaman,
Ivan Milovanović,
Miona Belović,
Milena Rašeta,
Tanja Radusin,
Nebojša Ilić
Publication year - 2016
Publication title -
hemijska industrija
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.147
H-Index - 19
eISSN - 2217-7426
pISSN - 0367-598X
DOI - 10.2298/hemind141229017n
Subject(s) - dpph , chemistry , antioxidant , quinic acid , ethanol , mushroom , traditional medicine , mtt assay , food science , biochemistry , apoptosis , medicine
The aim of this work was to study chemical profile and antioxidant and cytotoxic activities of ethanol and water extracts of Lactarius controversus (Pers.) 1800 mushroom species growing in eastern Serbia. The chemical characterization of phenolic compounds performed by HPLC-MS/MS demonstrated the presence of quinic acid among others. Determination of antioxidant activity, including radical scavenging effects on DPPH•, NO•, OH• and SOA radicals and ferric reducing ability was investigated. The highest DPPH radical scavenging effect was obtained for water extract (LcAq) while ethanol extract (LcEtOH) demonstrated the highest FRAP activity. Hexane extract applied in antibacterial assay against three pathogenic strains demonstrated antibacterial effect only against S. aureus ATCC25922. Anti-proliferative properties against estrogen dependent MCF 7 breast cancer cell lines using MTT showed higher activity for ethanolic extract. [Projekat Ministarstva nauke Republike Srbije, br. III 46001 i br. 172058