Open AccessSuccinimides: Synthesis, properties and anticonvulsant activity
Author(s) -
Nebojša Banjac,
Nemanja Trišović,
Nataša V. Valentić,
Gordana S. Ušćumlić,
Slobodan Petrović
Publication year - 2011
Publication title -
hemijska industrija
Language(s) - English
Resource type - Journals
eISSN - 2217-7426
pISSN - 0367-598X
DOI - 10.2298/hemind110224030b
Subject(s) - succinimides , succinimide , lipophilicity , chemistry , imide , anticonvulsant , combinatorial chemistry , organic chemistry , psychology , neuroscience , epilepsy
Succinimide is a cycle imide of succinic acid that is present in numerous biologically active compounds including anticonvulsants, antitremor, anti-Parkinson`s agents. This paper describes different ways of synthesis of succinimide-derivatives their physical properties and reactivity. Also, the most widely used succinimide anticonvulsants and the analysis of structure-activity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here