Succinimides: Synthesis, properties and anticonvulsant activity | Zendy

Nebojša Banjac | Zendy; Nemanja Trišović | Zendy; Nataša Valentić | Zendy; Gordana Uščumlić | Zendy; Slobodan Petrović | Zendy

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Succinimides: Synthesis, properties and anticonvulsant activity

Author(s) -

Nebojša Banjac,

Nemanja Trišović,

Nataša Valentić,

Gordana Uščumlić,

Slobodan Petrović

Publication year - 2011

Publication title -

hemijska industrija

Language(s) - English

Resource type - Journals

eISSN - 2217-7426

pISSN - 0367-598X

DOI - 10.2298/hemind110224030b

Subject(s) - succinimides , succinimide , lipophilicity , chemistry , imide , anticonvulsant , combinatorial chemistry , organic chemistry , psychology , neuroscience , epilepsy

Succinimide is a cycle imide of succinic acid that is present in numerous biologically active compounds including anticonvulsants, antitremor, anti-Parkinson`s agents. This paper describes different ways of synthesis of succinimide-derivatives their physical properties and reactivity. Also, the most widely used succinimide anticonvulsants and the analysis of structure-activity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here

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