Open AccessSystematic analysis of trimazolin hydrochloride as adrenergic vasoconstrictor
Author(s) -
Goran Nikolić,
Ivana Savić,
Vladimir Banković
Publication year - 2008
Publication title -
hemijska industrija
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.147
H-Index - 19
eISSN - 2217-7426
pISSN - 0367-598X
DOI - 10.2298/hemind0802069n
Subject(s) - chemistry , hydrochloride , chromatography , high performance liquid chromatography , organic chemistry
Trimazolin-hydrochloride, which is used as a pharmaceutically active component (adrenergic vasoconstrictor) for the production of decongestive preparations, was investigated in this paper by performing systematic analysis. In domestic and foreign pharmacopoeias, as well as in scientific and patent literature, there are no data on trimazolin and the methods of its investigation. Systematic analysis involves two investigation phases. A complete physicochemical characterization of the synthesized substance was done by previous investigation. In the second phase, a chemical structure of the synthesized pharmacologically active substance was confirmed to a certain degree of certainty by using the absorption spectroscopic methods (FTIR, UV-VIS, 1H-NMR). The spectroscopic methods used proved to be successful at identifying and investigating the purity of trimazolin hydrochloride. Liquid (RP-HPLC) chromatography was used for the analysis of trimazolin hydrochloride in the nasal preparation (Adrianol). The method of titrimetric analysis was developed with the aim of quantitative determination of trimazolin hydrochloride in decongestive preparations