Open AccessThe characteristics of novel dosage forms
Author(s) -
Jela Milić-Aškrabić,
Slobodan Petrović
Publication year - 2003
Publication title -
hemijska industrija
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.147
H-Index - 19
eISSN - 2217-7426
pISSN - 0367-598X
DOI - 10.2298/hemind0310424m
Subject(s) - active ingredient , drug , dosage form , drug delivery , drug administration , site of action , biochemical engineering , pharmacology , pharmaceutical sciences , active principle , medicine , nanotechnology , materials science , traditional medicine , engineering
The objective of pharmaceutical-technological development is to find a procedure of transforming an active substance (a drug) into a drug dosage form which is not only acceptable for application, but also enables the active substance to be released following administration, pursuant to therapy objectives. The aim is that the concentration of the active substance in the action location rapidly reaches a therapeutic level and maintains an approximately constant level in the course of a particular time, according to the established therapeutic goal. The primary objective is to present the active ingredient (drug) in the form and concentration/quantity that enables the corresponding therapeutic response, i.e. to control the site and rate of medicinal substance release from the drug, as well as the rate at which it reaches the membranes and surfaces to which it is absorbed, while applying a common method of administration. The procedures used to achieve this goal are becoming highly complex and demanding and are aiming at sophisticated drug delivery systems and functional packaging material. Development from the existing drug molecule, through the conventional drug dosage form, to a new system of drug "delivery" (novel delivery system), can improve the drug (active substance) characteristics significantly in view of compliance (acceptability by the patient), safety and efficiency. The paper presents an overview of the most important examples of pharmaceutical forms with controlled release and advanced drug "carriers"