Open AccessSynthetic approaches to coniine and other 2-alkyl piperidines
Author(s) -
Marija S. Denić,
Polina D. Blagojević,
Niko S. Radulović
Publication year - 2013
Publication title -
facta universitatis. series: physics, chemistry and technology
Language(s) - English
Resource type - Journals
eISSN - 2406-0879
pISSN - 0354-4656
DOI - 10.2298/fupct1301001d
Subject(s) - enantioselective synthesis , piperidine , alkaloid , chemistry , stereochemistry , organic chemistry , catalysis
The first synthesis of coniine, a neurotoxic piperidine alkaloid found in poison hemlock (Conium maculatum L.), was performed back in 1886 by Ladenburg. Since that time, numerous different approaches to the synthesis of this and related alkaloids (2-alkylpiperidines) have been developed. Nowadays, the enantioselective/specific synthesis of coniine is taken as a paradigm of the usefulness of new chiral synthetic methodologies. This review aims to summarize and systematize recent progress in the synthesis of coniine and related compounds. [Projekat Ministarstva nauke Republike Srbije, br. 172061