Open AccessSynthesis, characterization and antimicrobial activity of cobalt metal complex against multi drug resistant bacterial and fungal pathogens
Author(s) -
Subhasish Saha,
Dharumadurai Dhanasekaran,
Sarvanan Chandraleka,
A. Panneerselvam
Publication year - 2009
Publication title -
facta universitatis. series: physics, chemistry and technology
Language(s) - English
Resource type - Journals
eISSN - 2406-0879
pISSN - 0354-4656
DOI - 10.2298/fupct0901073s
Subject(s) - candida albicans , klebsiella pneumonia , microbiology and biotechnology , staphylococcus aureus , aspergillus flavus , antimicrobial , pseudomonas aeruginosa , aspergillus niger , aspergillus fumigatus , antibacterial activity , chemistry , biology , bacteria , biochemistry , genetics
Cobalt complex with histidine ligand was synthesized and physico-chemically characterized by solubility testing, melting point, UV-spectra and FTIR. The synthesized metal complex was evaluated for in-vitro antibacterial and antifungal activity against the multidrug resistant pathogens, such as Pseudomonas aeruginosa, Vibrio cholerae, Salmonella typhi, E. coli, Klebsiella pneumonia, Staphylococcus aureus, Aspergillus niger, Aspergillus flavus and Candida albicans. The metal complex showed the significant antibacterial and antifungal activity comparison with commercial antibiotics. Further work can be extended through In-silico docking of this metal complex and bacterial, fungal genome which can be given a better idea about genome metal interaction in molecular level