Open AccessOptimisation method used for aluminium-based antacid preparation
Author(s) -
Mladen Pavlović,
Savo Jovanović,
S Ljiljana Prazic-Arsic,
M Milanka Vico-Stevanovic,
R Svetlana Trajkovic
Publication year - 2007
Publication title -
chemical industry and chemical engineering quarterly
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.189
H-Index - 26
eISSN - 2217-7434
pISSN - 1451-9372
DOI - 10.2298/ciceq0702060p
Subject(s) - thixotropy , rheology , box–behnken design , suspension (topology) , response surface methodology , materials science , antacid , viscosity , colloid , ingredient , chemical engineering , chromatography , mathematics , chemistry , composite material , engineering , biochemistry , food science , homotopy , pure mathematics
The aim of this work was to optimize the rheological properties of AlPO4 suspension, the main ingredient of the antacid preparation - Alfogel. The exact rheological characterisation of the system is very important due to its stability and transportation through the pipe system into the reaction vessel. Box-Behnken design was used to estimate the effect of the concentrations of cations and the content of active pharmaceutical ingredient on the rheological properties of the system. The relationship between one or more response functions and a set of independent variables can be examined by using response surface methods, such as Box-Behnken designs. The concentration of Na+ and Mg2+ ions as well as the content of AIPO4, ranged from the optimum set of conditions to their minimum and maximum values. The viscosity, yield stress point and thixotropy of the colloidal system were used to assess the rheological properties of the AIPO4 suspension. The system was characterised using a second order polynomial mathematical model. The process was optimised and the proposed model was confirmed in laboratory scale experiments.