Open AccessThe investigation of primary physicochemical and pharmaco-biological properties of polynuclear iron(III) complexes with dextran and its derivatives
Author(s) -
Dragan M. Cvetković,
Vesikolić,
Ljubiša Nikolić
Publication year - 2005
Publication title -
chemical industry and chemical engineering quarterly
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.189
H-Index - 26
eISSN - 2217-7434
pISSN - 1451-9372
DOI - 10.2298/ciceq0501030c
Subject(s) - dextran , chemistry , hydrolysis , decomposition , chelation , viscosity , nuclear chemistry , biochemistry , inorganic chemistry , organic chemistry , materials science , composite material
The results of the investigations of primary physicochemical and pharmaco-biological properties of polynuclear iron(III) complexes with low molecular dextran (LMD), hydrogenated low molecular dextran (H-LMD) and dextran carbonic acid (DCA) are presented. The investigations included the complex resistance to hydrolytic decomposition in highly acidic medium, the (TFH-A)-value, and neutral medium at 120?C, the (TFH-120)-value, the viscosity of the parenteral solutions, iron(III) resorption dynamics to serum after the i.m. and i.v. application of the preparation to rabbits, the acute toxicity (LD50) in mice, and the residual iron(III) quantity at the i.m. application site. Iron(III) complexes with dextran carbonic acid (DCA) appeared to be the most suitable for use in veterinary and human medicine.